Welcome to LookChem.com Sign In|Join Free

Article Doi

Efficient synthesis of (±)-seco-cyclopropaneindoline analogs of CC-1065

DOI: 10.1515/HC.2001.7.1.7

Source and publish data:

Heterocyclic Communications p. 7 - 16 (2001)

Update date:2022-07-30

Topics:

Authors:

Jennings, Sharon A.Jennings, Sharon A.

Toth, James L.Toth, James L.

Roller, Shane G.Roller, Shane G.

Brooks, NatalieBrooks, Natalie

O'Hare, CarolineO'Hare, Caroline

Kiakos, KonstantinosKiakos, Konstantinos

Hartley, John A.Hartley, John A.

Burke, Philip J.Burke, Philip J.

Lee, MosesLee, Moses

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1515/HC.2001.7.1.7

An efficient method for the preparation of racemic seco-cyclopropaneindoline, or seco-CI, analogs of the anticancer agent CC1065 is described. The syntheses of seco-CI compounds containing either 5,6,7-trimethoxyindole-2-carbonyl, 4, or 5-(benzofuran-2-carboxamido)indole-2-carbonyl, 10, or 2-(4-N,N-diethyl)aminophenyl)benzimidazole-6-carbonyl, 11, or 4-(4-butanamido-1-methylpyrrole-2-carboxamido)-1-methylpyrrole-2-carbonyl, 12, subunit are detailed. At μM concentrations, compounds 4, 10-12 inhibited the growth of human leukemic K562 cells in culture.

View More

Full text of DOI:10.1515/HC.2001.7.1.7

Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/6/15 5:03 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/6/15 5:03 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/6/15 5:03 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/6/15 5:03 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/6/15 5:03 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/6/15 5:03 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/6/15 5:03 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/6/15 5:03 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/6/15 5:03 AM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 6/6/15 5:03 AM  

Products guided by the article

Product name:4-butyrylamino-1-methyl-1H-pyrrole-2-carboxylic acid [5-(6-benzyloxy-3-chloromethyl-2,3-dihydro-indole-1-carbonyl)-1-methyl-1H-pyrrol-3-yl]-amide

Cas No:351890-41-0

351890-41-0

R&D Labs maybe for 351890-41-0

Relevant to this article

Hot Product