INVESTIGATION ON THE STEREODIRECTION OF THE RITTER REACTION. CRYSTALLINE AND MOLECULAR STRUCTURES OF N-(2-PHENETHYL)-2,5-DIMETHYL-4-PHENYLPIPERID-4-OL AND N-(2-PHENETHYL)-2,5-DIMETHYL-4-PHENYL-4-ACETAMIDOPIPERIDINE

Article abstract of DOI:10.1007/BF01184885

The stereodirection of the Ritter reaction of N-(2-phenethyl)-2,5-dimethyl-4-phenylpiperid-4-ol to the corresponding amide has been studied.X-ray analysis has shown that the reaction occurs with retention of the configuration about atom C4 of the piperidine ring.