Tetrahedron p. 1267 - 1272 (1988)
Update date:2022-08-05
Topics:
Baraldi, P. G.
Barco, A.
Benetti, S.
Casolari, A.
Manfredini, S.
et al.
A new synthesis of geiparvarin 1 and its dihydroderivative 2, two naturally occuring antitumor agents, possessing the 3(2H)-furanone ring system central structural feature, is described.The synthetic design is based on the use of suitably substituted isoxazole derivatives, the heterocyclic ring acting as masked 1,3-diketone moiety.
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