Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist

Article abstract of DOI:10.1021/jm00120a004

Etoxadrol (2a), one of the eight possible optical isomers of 2-ethyl-2-phenyl-4-(2-piperidyl)-1,3-dioxolane, was synthesized from (S,S)-1-(2-piperidyl)-1,2-ethanediol, which was obtained from cleavage of dexoxadrol (1a, (S,S)-2,2-di-phenyl-4-(2-piperidyl)