PREPARATION OF BRASSYLIC ACID FROM 5,6,7,8,9,10,11,12,13,14-DECAHYDROCYCLODODECAPYRIMIDINE(1H,3H)-2,4-DIONE OBTAINED BY THE CONDENSATION OF CYCLODODECANONE AND UREA OR BIURET

Article abstract of DOI:10.1007/BF00863946

A simple method is proposed for the preparation of brassylic acid by the alkaline hydrolysis of 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca<1,2-d>pyrimidine<1H,3H)dione-2,4, which is the product of the condensation of cyclododecanone with urea or biuret.The condensation of the cyclododecanone with thiourea proceeds differently, leading to 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca<1,2-d>pyrimidine(1H,3H)spirocyclododecane-2-thione-4. Keywords: brassylic acid, cyclododecanone, 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca<1,2-d>pyrimidine(1H,3H)dione-2,4, 5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca<1,2-d>pyrimidinespirocyclododecane-2-thione-4, urea, biuret, methoxycarbonylcyclododecanone, phenylamide of cyclododecanonecarboxylic acid.