Journal of Medicinal Chemistry p. 1194 - 1197 (1974)
Update date:2022-08-05
Topics:
Vida
Samour
O'Dea
Wang
Several 5 substituted 5 (1 phenylethyl)barbituric acids displayed potent analgesic activity. One compound, 5 acetoxy 5 (1 phenylethyl)barbituric acid, exhibited better analgesic activity than codeine orally and had one thirds of the analgesic potency of morphine when administered subcutaneously. Another compound, 5 cyclopropylcarbonyloxy 5 (1 (phenylethyl)barbituric acid, exhibited better analgesic activity than codeine orally and was approximately 10 times as potent as morphine when administered subcutaneously. Three other compounds also revealed better analgesic activity than codeine orally.
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