Journal of Organic Chemistry p. 5984 - 5991 (2015)
Update date:2022-08-03
Topics:
Gao, Qinghe
Liu, Shan
Wu, Xia
Zhang, Jingjing
Wu, Anxin
A highly efficient I2-catalyzed Povarov-type reaction of methyl ketones, arylamines, and α-ketoesters is developed. This reaction utilizes a catalytic amount of HI coproduct as a promoter for the synthesis of substituted quinolones. This simple procedure represents an interesting new form of reactivity for the Povarov reaction with good functional group compatibility.
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