In search of new organophosphorus pesticides and insecticides. Part III: Synthesis and anticholinesterase studies of 3-(subs)-quinoxy/pyridinoxy/cyclica mino-2,3-dihydro-2-(4-chlorophenyl)-1H-naphth [1,2-E][1,3,2] oxazaphosphorine 3-sulfides

Article abstract of DOI:10.1080/10426500008082383

In situ treatment of (cyclic) amino derivatives with the product obtained from the cyclocondensation of 1-p-chloroanilinomethyl naphthol-2 and thiophosphoryl chloride in dry benzene-THF afforded the titled oxazaphosphorine sulfides in good yield. Subsequently, the reaction of pyridinoxy/quinoxythiophosphorodi chloridates and 1-p-chloro anilino methyl naphthol-2 in dry benzene-THF mixture gave the corresponding pyridinoxy/quinoxy oxaza phosphorine 3-sulfides in quantitative yield. All the condensations proceeded smoothly by employing triethylamine to scavenge the liberated hydrogen chloride gas. Anticholinestease studies of these compounds indicated very high degree of inhibition several times higher than the reference standard-methyl parathion.

Full text of DOI:10.1080/10426500008082383

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Phosphorus, Sulfur, and
Silicon and the Related
Elements
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In Search of new
Organophosphorus
Pesticides and Insecticides.
Part III: Synthesis and
Anticholinesterase Studies
of 3-(Subs)-Quinoxy/
Pyridinoxy/Cyclica
Mino-2,3- Dihydro-2-
(4-Chlorophenyl)-1H-
Naphth [1,2-E][1,3,2]
Oxazaphosphorine 3-Sulfides
E. O. John Bull a & M. S. R. Naidu b
a Department of Chemistry , Bayero University ,
P.M.B., 3011, Kano, Nigeria
b Department of Chemistry , Sri Venkateswara
University Tirupati , 517 502, (A P), India
Published online: 03 Jan 2007.
To cite this article: E. O. John Bull & M. S. R. Naidu (2000) In Search of
new Organophosphorus Pesticides and Insecticides. Part III: Synthesis and
Anticholinesterase Studies of 3-(Subs)-Quinoxy/Pyridinoxy/Cyclica Mino-2,3-
Dihydro-2-(4-Chlorophenyl)-1H-Naphth [1,2-E][1,3,2] Oxazaphosphorine 3-
Sulfides, Phosphorus, Sulfur, and Silicon and the Related Elements, 167:1, 9-20,
DOI: 10.1080/10426500008082383

To link to this article: http://dx.doi.org/10.1080/10426500008082383
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