Diastereoselectivity in the methylation and reduction of 3-aryl- 3a,4,5,6,7,7a-hexahydro-1,2-benzisoxazol-4-ones

Article abstract of DOI:10.3987/com-98-8438

Various 3-aryl-3a,4,5,6,7,7a-hexahydro-1,2-benzisoxazol-4-ones were methylated at 3a-positions and reduced by NaBH₄ to afford the corresponding 3a,4-cis-3a,7a-cis-3a-methyl-3a,4,5,6,7,7a-hexahydro-1,2-benzisoxazol-4-ols with excellent diastereo