Copper(II)-catalyzed highly enantioselective addition of enamides to imines: The use of einamides as nucleophiles in asymmetric catalysis

Article abstract of DOI:10.1002/anie.200353237

High-yielding efficient routes to optically active amino acid and 1,3-diamine derivatives have been achieved by the catalytic enantioselective addition of enamides to imines using a chiral copper catalyst (see scheme). This reaction demonstrates the utili