Synthetic Communications p. 4265 - 4271 (2008)
Update date:2022-09-26
Topics:
Anumula, Raghupathi Reddy
Madivada, Lokeswara Rao
Gilla, Goverdhan
Raju, V. V. N. K. Prasad
Kagga, Mukkanti
Reddy, Padi Pratap
Bhattacharya, Apurba
Bandichhor, Rakeshwar
Two-step alternative synthesis of tadalafil (1) is described. The synthesis features Pictet-Spengeler type reaction and DCC (N,N′- dicyclohexylcarbodiimide)/HOBt (N-hydroxybenzotriazole)-mediated double amidation employing sarcosine ethyl ester hydrochlor
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