Alternative synthesis of tadalafil: PDE5 inhibitor

DOI: 10.1080/00397910802326521

Source and publish data:

Synthetic Communications p. 4265 - 4271 (2008)

Update date:2022-09-26

Topics:

Authors:

Anumula, Raghupathi Reddy

Madivada, Lokeswara Rao

Gilla, Goverdhan

Raju, V. V. N. K. Prasad

Kagga, Mukkanti

Reddy, Padi Pratap

Bhattacharya, Apurba

Bandichhor, Rakeshwar

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Article abstract of DOI:10.1080/00397910802326521

Two-step alternative synthesis of tadalafil (1) is described. The synthesis features Pictet-Spengeler type reaction and DCC (N,N′- dicyclohexylcarbodiimide)/HOBt (N-hydroxybenzotriazole)-mediated double amidation employing sarcosine ethyl ester hydrochlor

Full text of DOI:10.1080/00397910802326521

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Product name:(1R,3R)-1-(1,3-benzodioxol-5-yl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid

Cas No:406938-39-4

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