Bioorganic and Medicinal Chemistry p. 393 - 396 (1997)
Update date:2022-09-26
Topics:
Kerdesky, Francis A.J.
Brooks, Clint D.W.
Hulkower, Keren I.
Bouska, Jennifer B.
Bell, Randy L.
Representative examples of NSAID cyclooxygenase inhibitors such as naproxen, ibufenac, ibuprofen, and butibufen have been transformed into 5-lipoxygenase inhibitors by replacement of the carboxylic acid moiety with a 4-hydroxythiazole group.
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