Serine-Protease-Assisted Synthesis of Peptide Substrates for α-Chymotripsin

DOI: 10.1002/hlca.19820650605

Source and publish data:

Helvetica Chimica Acta p. 1707 - 1719 (1982)

Update date:2022-08-05

Topics:

Authors:

Bizzozero, Spartaco A.

Rovagnati, Bruno A.

Dutler, Hans

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Article abstract of DOI:10.1002/hlca.19820650605

δ-Chymotrypsin catalyzes peptide-bond formation between acylated amino-acid and peptide esters as the carboxyl component and amino-acid and peptide amides as the amino component.The conditions under which enzyme-catalyzed coupling can be used for fragment condensation in peptide synthesis is investigated.To illustrate the method the synthesis of tetra-, penta and hexapeptides of the structure Ac-L_xn-...-L_xl-L_yl-...-L_ym-NH2 with L_xl = Tyr, designed as substrates for α-chymotrypsin is described.

Full text of DOI:10.1002/hlca.19820650605

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