Helvetica Chimica Acta p. 1707 - 1719 (1982)
Update date:2022-08-05
Topics:
Bizzozero, Spartaco A.
Rovagnati, Bruno A.
Dutler, Hans
δ-Chymotrypsin catalyzes peptide-bond formation between acylated amino-acid and peptide esters as the carboxyl component and amino-acid and peptide amides as the amino component.The conditions under which enzyme-catalyzed coupling can be used for fragment condensation in peptide synthesis is investigated.To illustrate the method the synthesis of tetra-, penta and hexapeptides of the structure Ac-Lxn-...-Lxl-Lyl-...-Lym-NH2 with Lxl = Tyr, designed as substrates for α-chymotrypsin is described.
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