Toward an optimal joint recognition of the s1′ subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP)

DOI: 10.1021/jm0005454

Source and publish data:

Journal of Medicinal Chemistry p. 1477 - 1486 (2002)

Update date:2022-08-03

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Authors:

Inguimbert, Nicolas

Coric, Pascale

Poras, Hervé

Meudal, Hervé

Teffot, Franck

Fournié-Zaluski, Marie-Claude

Roques, Bernard P.

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Article abstract of DOI:10.1021/jm0005454

The formation of vasoconstrictors (e.g., angiotensin II and endothelin) and the inactivation of vasodilators (e.g., bradykinin and atrial natriuretic) by membrane-bound zinc metallopeptidases are key mechanisms in the control of blood pressure and fluid h

Full text of DOI:10.1021/jm0005454

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