Chemistry of Heterocyclic Compounds p. 663 - 666 (1986)
Update date:2022-08-04
Topics: Yield Bromination Reaction Time Product Thiazole Reactant
Gol'dfarb, Ya. L.
Gromova, G. P.
Belen'kii, L. I.
Bromination of thiazole by bromine in the presence of aluminium chloride in neutral solvent or without solvent takes place at the 2-position.Such an orientation contradicts the traditional addition-cleavage mechanism, and agrees with the ylid mechanism of electrophilic substitution. 2-Methylthiazole brominates at the 5-position, and the reaction is impeded in the presence of aluminium chloride; this is due to heterocycle deactivation by complexation with the Lewis acid at the nitrogen atom.
View MoreContact:+86 021-51698675
Address:1701, Jielong Plaza, No.618 Pingliang Rd, ShangHai,China
website:http://www.hope-chem.com
Contact:86-21-58090396-805
Address:Floor 4, Building 5, No.588 Tianxiong Road, Zhoupu International Medical Zone, ShangHai, China
Luoyang Aoda chemical Co.,Ltd.
Contact:+86-379-67518785 67516588
Address:MiaoWan industry district,YanShi City,Henan,China
Contact:+86-021-50792271
Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Nanjing Qirui Material Co., Ltd.
Contact:+86-25-52320053
Address:F4-5, #17 Building, Chuang Yi Yuan, No.6 Guanghua East Street, Nanjing, 210007 P.R.China
Doi:10.1021/ja01171a046
(1949)Doi:10.1002/anie.201200961
(2012)Doi:10.1021/ja00792a035
(1973)Doi:10.1021/ol050386o
(2005)Doi:10.1007/s10973-010-1024-1
(2011)Doi:10.1021/ja01354a040
(1931)