Chemistry of Heterocyclic Compounds p. 663 - 666 (1986)
Update date:2022-08-04
Topics: Yield Bromination Reaction Time Product Thiazole Reactant
Gol'dfarb, Ya. L.
Gromova, G. P.
Belen'kii, L. I.
Bromination of thiazole by bromine in the presence of aluminium chloride in neutral solvent or without solvent takes place at the 2-position.Such an orientation contradicts the traditional addition-cleavage mechanism, and agrees with the ylid mechanism of electrophilic substitution. 2-Methylthiazole brominates at the 5-position, and the reaction is impeded in the presence of aluminium chloride; this is due to heterocycle deactivation by complexation with the Lewis acid at the nitrogen atom.
View MoreHangzhou Peptidego Biotech Co.,Ltd
Contact:0571-87213919
Address:6-204,No.688,Bin'an road,Changhe street,BinJiang district,Hangzhou,Zhejiang,CN
Qingdao Kingway Pharmtech Co., Ltd.
Contact:86-532-87118899
Address:No. 88, Middle Haixi Road, Jiaonan City, Qingdao, China
Contact:886 2 2541 0022
Address:8 Fl., No. 11, Sec. 1, Chung Shan North Rd., Taipei, Taiwan R.O.C.
Contact:+86-27-85733560
Address:NO.308,QINGNIAN RD.,WUHAN,CHINA
Nanjing Yuance Industry&Trade Co., Ltd.
website:http://www.njyuance.cn/
Contact:+86-25-85439097
Address:B1702, Aoti Bldg, No. 130, Aoti Avenue, Nanjing, China
Doi:10.1021/ja01171a046
(1949)Doi:10.1002/anie.201200961
(2012)Doi:10.1021/ja00792a035
(1973)Doi:10.1021/ol050386o
(2005)Doi:10.1007/s10973-010-1024-1
(2011)Doi:10.1021/ja01354a040
(1931)
