Pyrazole-O-glucosides as novel Na+-glucose cotransporter (SGLT) inhibitors

DOI: 10.1016/S0960-894X(03)00466-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2269 - 2272 (2003)

Update date:2022-07-30

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Authors:

Ohsumi, Koji

Matsueda, Hiroyuki

Hatanaka, Toshihiro

Hirama, Ryusuke

Umemura, Takashi

Oonuki, Akiko

Ishida, Nozomu

Kageyama, Yoko

Maezono, Katsumi

Kondo, Nobuo

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Article abstract of DOI:10.1016/S0960-894X(03)00466-9

O-glucuronides and O-glucosides of a series of pyrazoles analogues were synthesized and evaluated for their SGLT inhibitory activity in brush border membrane vehicles (BBMVs) of rat kidney. O-glucosides of certain pyrazole analogues inhibited the transport of [¹⁴C]-glucose in BBMVs, and induced glucosuria in Wistar rats by intravenous injection.

Full text of DOI:10.1016/S0960-894X(03)00466-9

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