Tetrahedron Letters p. 341 - 344 (1991)
Update date:2022-08-05
Topics:
Klempier
De Raadt
Faber
Grieng
Using an immobilized nitrilase from Rhodococcus sp. mild and selective hydrolysis of nitriles can be achieved even in the presence of acid or base sensitive groups under neutral conditions. This method is applicable to a broad range of substrates as exemplified by aliphatic, alicyclic, heterocyclic and carbohydrate type nitriles.
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