Selective transformation of nitriles into amides and carboxylic acids by an immobilized nitrilase

Article abstract of DOI:10.1016/S0040-4039(00)92623-6

Using an immobilized nitrilase from Rhodococcus sp. mild and selective hydrolysis of nitriles can be achieved even in the presence of acid or base sensitive groups under neutral conditions. This method is applicable to a broad range of substrates as exemplified by aliphatic, alicyclic, heterocyclic and carbohydrate type nitriles.