Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha

DOI: 10.1016/S0960-894X(01)00732-6

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Bioorganic and Medicinal Chemistry Letters p. 333 - 335 (2002)

Update date:2022-08-05

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Authors:

Miyachi, Hiroyuki

Nomura, Masahiro

Tanase, Takahiro

Suzuki, Masahiro

Murakami, Koji

Awano, Katsuya

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Article abstract of DOI:10.1016/S0960-894X(01)00732-6

Optically active phenylpropanoic acid derivatives [(S)-5, and (R)-5] were prepared, and their affinities for peroxisome proliferator-activated receptor (PPAR)α and PPARγ were evaluated. Binding assay and cell-based reporter assay indicated that the activi

Full text of DOI:10.1016/S0960-894X(01)00732-6

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