One-pot synthesis and aromatization of 1,4-dihydropyridines in refluxing water

Article abstract of DOI:10.1055/s-2005-870022

A series of 1,4-dihydropyridines were synthesized in an environmentally benign method, by reacting aldehydes with acetoacetate esters or acetylacetone and ammonium acetate in refluxing water. The thus formed 1,4-dihydropyridines was subsequently oxidized in one-pot to the corresponding pyridine derivatives by either ferric chloride or potassium permanganate. Georg Thieme Verlag Stuttgart.