Grubbs' RCM in the total synthesis of the microtubule stabilizing drug laulimalide

DOI: 10.1002/1615-4169(200208)344:6/7<573::AID-ADSC573>3.0.CO;2-C

Source and publish data:

Advanced Synthesis and Catalysis p. 573 - 584 (2002)

Update date:2022-07-30

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Authors:

Mulzer, Johann

Oehler, Elisabeth

Enev, Valentin S.

Hanbauer, Martin

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Article abstract of DOI:10.1002/1615-4169(200208)344:6/7<573::AID-ADSC573>3.0.CO;2-C

Two independent syntheses of the microtubule stabilizing antitumor agent laulimalide are described, which mainly differ with respect to the macrocyclization step. The first synthesis employs a Still-Gennari olefination and the second one an Alexakis-type,

Full text of DOI:10.1002/1615-4169(200208)344:6/7<573::AID-ADSC573>3.0.CO;2-C

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