Synthesis and mechanistic aspects of 2-anilinonicotinyl-pyrazolo[1,5-a]pyrimidine conjugates that regulate cell proliferation in MCF-7 cells via estrogen signaling

DOI: 10.1016/j.bmcl.2016.02.072

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2077 - 2083 (2016)

Update date:2022-08-04

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Authors:

Kamal, Ahmed

Faazil, Shaikh

Hussaini, S.M. Ali

Ramaiah, M. Janaki

Balakrishna

Patel, Nibedita

Pushpavalli

Pal-Bhadra, Manika

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Article abstract of DOI:10.1016/j.bmcl.2016.02.072

A series of anilinonicotinyl linked pyrazolo[1,5-a]pyrimidine conjugates (6a-x) were synthesized and evaluated for their antiproliferative activity. Some of these conjugates exhibited promising cytotoxic effects in the MCF-7 cell line and among these 6a a

Full text of DOI:10.1016/j.bmcl.2016.02.072

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