Pyrazole NNRTIs 4: Selection of UK-453,061 (lersivirine) as a Development Candidate

DOI: 10.1016/j.bmcl.2009.08.080

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5857 - 5860 (2009)

Update date:2022-07-30

Topics:

Authors:

Mowbray, Charles E.

Burt, Catherine

Corbau, Romuald

Gayton, Simon

Hawes, Michael

Perros, Manos

Tran, Isabelle

Price, David A.

Quinton, Faye J.

Selby, Matthew D.

Stupple, Paul A.

Webster, Rob

Wood, Anthony

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Article abstract of DOI:10.1016/j.bmcl.2009.08.080

We prepared three discreet cohorts of potent non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on the recently reported 3-cyanophenoxypyrazole lead 3. Several of these compounds displayed very promising anti-HIV activity in vitro, safety,

Full text of DOI:10.1016/j.bmcl.2009.08.080

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