Journal of Medicinal Chemistry p. 4706 - 4715 (2002)
Update date:2022-07-30
Topics:
Brady, Stephen F.
Pawluczyk, Joseph M.
Lumma, Patricia K.
Feng, Dong-Mei
Wai, Jenny M.
Jones, Raymond
DeFeo-Jones, Deborah
Wong, Bradley K.
Miller-Stein, Cynthia
Lin, Jiunn H.
Oliff, Allen
Freidinger, Roger M.
Garsky, Victor M.
Chemotherapy of prostate cancer with antimitotic agents such as vinblastine and doxorubicin is only marginally effective, due to dose-limiting systemic toxicity. Herein we report the development of peptidyl conjugate 5 of the cytotoxic agent vinblastine (
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