Conformationally Constrained Analogues of Diacylglycerol. 20. The Search for an Elusive Binding Site on Protein Kinase C through Relocation of the Carbonyl Pharmacophore Along the sn-1 Side Chain of 1,2-Diacylglycerol Lactones

DOI: 10.1021/jm030454h

Source and publish data:

Journal of Medicinal Chemistry p. 644 - 655 (2004)

Update date:2022-08-03

Topics:

Authors:

Tamamura, Hirokazu

Sigano, Dina M.

Lewin, Nancy E.

Blumberg, Peter M.

Marquez, Victor E.

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Article abstract of DOI:10.1021/jm030454h

Previous studies with 1,2-diacylglycerol (DAG) lactones, which behave as high-affinity ligands for protein kinase C (PK-C), have established the importance of maintaining intact the pharmacophore triad of two carbonyl moieties (sn-1 and sn-2) and the prim

Full text of DOI:10.1021/jm030454h

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