Synthesis of a novel tricyclic 4-quinolone. Incorporation of a spiro-cyclopropyl group at N1 by bridging to C2

Article abstract of DOI:10.1002/jhet.5570250632

An important pharmacophore in many quinolone antiinfectives is the N1 cyclopropane. By incorporating the cyclopropane into a N1 to C2 bridge, the first quinolone substrate incorporating a spiro fused cyclopropane, 8,9,10-trifluoro-2,3,4,6-tetrahydro-6-oxo