Journal of Heterocyclic Chemistry p. 1769 - 1772 (1988)
Update date:2022-08-05
Topics:
Schroeder
Kiely
An important pharmacophore in many quinolone antiinfectives is the N1 cyclopropane. By incorporating the cyclopropane into a N1 to C2 bridge, the first quinolone substrate incorporating a spiro fused cyclopropane, 8,9,10-trifluoro-2,3,4,6-tetrahydro-6-oxo
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