Journal of Pharmaceutical Sciences p. 185 - 187 (1988)
Update date:2022-08-04
Topics:
Gaudreault
lacroix
Page
Joly
1-Aryl-3-(2-chlorethyl) ureas and 1-aryl-3-nitrose-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanillines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro. Methyl 4-[p-[3-(2-chloroethyl)ureido]-phenyl]butyrate, 4-methyl [3-(2-chloroethyl)ureido]benzene, and 4-butyl[3-(2-chloroethyl)ureido]benzene were found to be at least as cytotoxic as 4-[p-[bis-(2-chloroethyl)amino]phenyl]butyric acid (chlorambucil), while their N-nitrose derivatives were inactive.
View MoreShao Xing Empire Import&Export CO.,ltd
Contact:86-575-82127757
Address:11#, Weiwu Road, Shangyu Industrial Park, Hangzhou Bay, Hangzhou, Zhejiang Province, China
Henan Allgreen Chemical Co.,Ltd
website:http://www.allgreenchem.com
Contact:+86-0371-87507775
Address:No 260 Dongming Road,Jinshui District
Shanghai ShengShan chemical technology co., LTD
Contact:86-0-18964748206
Address:95,East century street,Jinshan,Shanghai,China
website:http://www.sagechem.com
Contact:+86-571-86818502
Address:Room C1301, New Youth Plaza, 8 Jia Shan Road, Hangzhou, China
Hubei Xiangxi Chemical Industry Co.,Ltd
Contact:+86-710-3454830
Address:No.7, Daqing East Road, Xiangfan City, Hubei Province, China
Doi:10.1021/jm00249a034
(1974)Doi:10.1021/ja954286x
(1996)Doi:10.1016/S0040-4039(01)87352-4
(1973)Doi:10.1021/jacs.9b07293
(2019)Doi:10.1016/S0040-4039(01)87646-2
(1973)Doi:10.1021/ja00336a070
(1984)
