Synlett p. 1379 - 1384 (2015)
Update date:2022-07-30
Topics:
De Azevedo, Orlando D. C. C.
Seixas, Raquel S. G. R.
Silva, Artur M. S.
A novel route for the synthesis of new (E)-8-styrylflavones is reported. This methodology involves the regio- and stereoselective Heck cross-coupling reaction of 8-iodoflavones and styrene derivatives. The Heck precursors, 8-iodoflavones, were obtained through an efficient regioselective one-pot oxidative cyclization-iodination reaction of (E)-2′-hydroxychalcones by applying the iodine/dimethyl sulfoxide system.
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