Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C)

DOI: 10.1021/jm020476o

Source and publish data:

Journal of Medicinal Chemistry p. 1571 - 1579 (2003)

Update date:2022-08-02

Topics:

Authors:

Sigano, Dina M.

Peach, Megan L.

Nacro, Kassoum

Choi, Yongseok

Lewin, Nancy E.

Nicklaus, Marc C.

Blumberg, Peter M.

Marquez, Victor E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm020476o

Diacylglycerol lactones (DAG lactones), analogous to highly potent diacylglycerols (DAGs) were synthesized to demonstrate the ability of PK-C to discriminate between two differential binding modes, sn-1 and sn-2. While both sn-1 and sn-2 binding modes are

Full text of DOI:10.1021/jm020476o

Products guided by the article

Product name:5,5-bis[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-3-(methylethylidene)-4,4-dihydrofuran-2-one

Cas No:528881-73-4

R&D Labs maybe for 528881-73-4

Compro Shijiazhuang Fine Chemical Co., Ltd

Contact:0086-311-89689838

Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Hubei Sky Lake Chemical Co., Ltd.

Contact:+86-27-87385545

Address:Te-2, Xijiao Chemical Park, Yuekou Town, Tianmen, Hubei, China.
Hunan Dinuo Pharmaceutical Co.,Ltd.

Contact:86-731-88280100*8561

Address:Bio-pharmaceutical industrial park, Liuyang, Hunan, China
Zhejiang Sanmei Chemical Industry Co., Ltd

Contact:86-579-87633213

Address:Huchu Industrial Zone, Qingnian Rd., Wuyi County, Zhejiang Prov., China.
Nanjing Fayekong Chemcial Co.,Ltd(expird)

Contact:86-25-58813444

Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China

Relevant to this article

Doi:10.1055/s-1974-23301
(1974)
Doi:10.1007/BF00472420
()
Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis -stilbene diamines: A platform for the preparation of single-enantiomer cis -imidazolines for protein-protein inhibition

Doi:10.1021/jo501003r
(2014)
Giant Enhancement of Second Harmonic Generation Accompanied by the Structural Transformation of 7-Fold to 8-Fold Interpenetrated Metal–Organic Frameworks (MOFs)

Doi:10.1002/anie.201911632
(2020)
Doi:10.1021/ja01018a020
(1968)
Hole-transfer catalyzed reaction: One-electron oxidation as a strategy for the selective cyclopropanation of π bonds

Doi:10.1016/S0040-4039(98)02163-7
(1998)

Article Doi