Journal of Medicinal Chemistry p. 1086 - 1090 (1974)
Update date:2022-08-04
Topics:
Saari
King
Lotti
Scriabine
Several aporphine derivatives related to apomorphine were synthesized and evaluated for antihypertensive and central dopaminergic activity. Apocodeine and (6aR) 10,11 methylenedioxyaporphine produced apomorphine like postural asymmetries in caudate lesioned mice but were less potent than apomorphine in this respect. Of the aporphine derivatives tested for antihypertensive activity, 11 hydroxyaporphine proved to be the most potent upon oral administration to spontaneously hypertensive rats.
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