Journal of Medicinal Chemistry p. 1086 - 1090 (1974)
Update date:2022-08-04
Topics:
Saari
King
Lotti
Scriabine
Several aporphine derivatives related to apomorphine were synthesized and evaluated for antihypertensive and central dopaminergic activity. Apocodeine and (6aR) 10,11 methylenedioxyaporphine produced apomorphine like postural asymmetries in caudate lesioned mice but were less potent than apomorphine in this respect. Of the aporphine derivatives tested for antihypertensive activity, 11 hydroxyaporphine proved to be the most potent upon oral administration to spontaneously hypertensive rats.
View MoreHubei Lingsheng Pharmaceuticals Co., Ltd.
Contact:+86-0710-3538058
Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
Jinan Hongfangde Pharmatech Co.LTD
Contact:0531-88870908
Address:F Bldg,750#,Shunhua Rd,New&High-tech Zone,Jinan,Shandong,China 250101
website:http://www.konochem.com
Contact:86-29-86107037
Address:No.170 West Avenue,Xi’an 710082,China
Onlychem (Jinan)Biotech Co.,Ltd
Contact:86-531-83175885
Address:No. 44, Honglou South Road, Jinan,China
NIGNXIA XINDACHANG TECHNOLOGY CO.,LTD
Contact:86-0951-7815345
Address:North side of Qiyuan Road, west side of Yuanfeng Highway, New Material Park, Ningdong Energy and Chemical Industry Base, Ningxia,China
Doi:10.1021/acs.orglett.6b02722
(2016)Doi:10.1021/jo00893a005
(1975)Doi:10.1039/c6gc02379g
(2016)Doi:10.1021/jm00256a021
(1974)Doi:10.1021/ja00818a025
(1974)Doi:10.1021/jm00256a016
(1974)
