Journal of Medicinal Chemistry p. 1086 - 1090 (1974)
Update date:2022-08-04
Topics:
Saari
King
Lotti
Scriabine
Several aporphine derivatives related to apomorphine were synthesized and evaluated for antihypertensive and central dopaminergic activity. Apocodeine and (6aR) 10,11 methylenedioxyaporphine produced apomorphine like postural asymmetries in caudate lesioned mice but were less potent than apomorphine in this respect. Of the aporphine derivatives tested for antihypertensive activity, 11 hydroxyaporphine proved to be the most potent upon oral administration to spontaneously hypertensive rats.
View MoreTianjin Pharmacn Medical Technology Co.,Ltd.
Contact:86-22-60122566ext.866(English),23359620
Address:Green Industrial Base, 6 Haitaifazhan Sixth Rd., Huayuan Industrial Area, Tianjin, 300384, China
Contact:+86-158-05817090
Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)
Contact:+86 021 50106671
Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park
Contact:0550-7041128 0550-7090578
Address:Wangdian Street,Xinjie Town
zhengzhou Triz Pharma-Tech Co., Ltd
website:http://www.Trizpharma-tech.com
Contact:+86-0371-86597269，53392065
Address:High-tech Industrial Development Zone, Zhengzhou City, NO.7 Holly Street
Doi:10.1021/acs.orglett.6b02722
(2016)Doi:10.1021/jo00893a005
(1975)Doi:10.1039/c6gc02379g
(2016)Doi:10.1021/jm00256a021
(1974)Doi:10.1021/ja00818a025
(1974)Doi:10.1021/jm00256a016
(1974)
