ASYMMETRIC ALDOL REACTION OF AN ISOCYANOACETATE WITH ALDEHYDES CATALYZED BY CHIRAL FERROCENYLPHOSPHINE-GOLD(I) COMPLEXES: DESIGN AND PREPARATION OF NEW EFFICIENT FERROCENYLPHOSPHINE LIGANDS

Article abstract of DOI:10.1016/S0040-4039(00)61850-6

An optically active ferrocenylphosphine ligand containing 2-(morpholino)ethylamino or 2-(piperidino)ethylamino group on the ferrocene side chain was effective for the goldcatalyzed aldol reaction of methyl isocyanoacetate with aldehydes to give optically active 4-methoxycarbonyl-5-alkyl-2-oxazolines (up to 96 percent ee) with high enantio- and diastereoselectivity in a quantitative yield.