Gas chromatography and mass spectrometry of derivatives of amino acids. Oxazolin-5-ones of several acyl-leucines.

Article abstract of DOI:10.1016/S0021-9673(01)81091-8

By the action of dicyclohexylcarbodiimide on fourteen different acyl-leucines in ethyl acetate solution, the corresponding oxazolin-5-ones were formed. The reaction was quantitative and very rapid. The oxazolin-5-ones were separated on a gas chromatograph on OV-7 and EGA columns. The mass spectra of the oxazolin-5-ones showed characteristic fragments that could be used for identification.