Bioorganic and Medicinal Chemistry Letters p. 2543 - 2546 (2004)
Update date:2022-07-29
Topics:
Barrett, David G.
Catalano, John G.
Deaton, David N.
Long, Stacey T.
Miller, Larry R.
Tavares, Francis X.
Wells-Knecht, Kevin J.
Wright, Lois L.
Zhou, Hui-Qiang Q.
An orally available series of ketoamide-based inhibitors of cathepsin K has been identified. Starting from a potent inhibitor with poor oral bioavailability, modifications to P1 and P 1′ elements led to enhancements in solubility and permeability. These improvements resulted in orally available cathepsin K inhibitors.
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