A facile method for the side-chain protection of α-methyl-β-3,4-dihydroxyphenyl-L-alanine (αMeDopa) for solid-phase peptide synthesis

Article abstract of DOI:10.1055/s-1991-26380

Two approaches have been used to prepare N(α)-tert-butoxycarbonyl-α-methyl-β-3,4-dimethoxy-, or dibenzyloxyphenyl-L-alanine, N(α)-Boc-α-MeDopa(R)₂, where R is the methyl or benzyl ether. In the first approach, α-methyl-β-3,4-dihydroxyphenyl-L-a