Resin-bound thiophenols as S(N)AR-labile linkers: Application to the solid phase synthesis of aminopyridazines

Article abstract of DOI:10.1016/S0040-4039(99)01533-6

A versatile approach for the solid phase synthesis of aminopyridazines was developed. Commercially available or novel resin-bound thiophenols are used to link 3,6-dichloropyridazine to solid supports and to introduce diversity into the molecule by direct cleavage of nucleophilic amines without oxidation to sulfones.