Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R

DOI: 10.1016/j.ejmech.2016.11.046

Source and publish data:

European Journal of Medicinal Chemistry p. 536 - 549 (2017)

Update date:2022-09-26

Topics:

Authors:

Mathi, Gangadhar Rao

Kang, Chung Hyo

Lee, Heung Kyoung

Achary, Raghavendra

Lee, Ha-Yeon

Lee, Joo-Youn

Ha, Jae Du

Ahn, Sunjoo

Park, Chi Hoon

Lee, Chong Ock

Hwang, Jong Yeon

Yun, Chang-Soo

Jung, Hee Jung

Cho, Sung Yun

Kim, Hyoung Rae

Kim, Pilho

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.ejmech.2016.11.046

The piperidine fragment in ceritinib was replaced with diverse aliphatic amines to improve inherent resistance issues of ceritinib. While most of the prepared compounds exhibit as similar in?vitro activities as ceritinib, compound 10 shows encouraging act

Full text of DOI:10.1016/j.ejmech.2016.11.046

Products guided by the article

Product name:2-(4-nitro-5-methoxy-2-methylphenyl)acetonitrile

Cas No:620604-72-0

R&D Labs maybe for 620604-72-0

Taizhou Chenyi chemical co. LTD,

Contact:13736652831

Address:NO.273 SHANGHAI SOUTH STREET,LUQIAO DISTRICT,ZHEJIANG PROVINCE,CHINA.
Zhangjiagang Jianing Import & Export Co.,Ltd.

Contact:086-512-55379012 13913607595

Address:NO.1 Guotai North Road Zhangjiagang Economic Development Zone,215600,Jiangsu,China
JIANGXI AIFEIMU TECHNOLOGY CO.，LTD

Contact:+86-570-6040289

Address:FINECHEMICAL PARK,ZIBU TOWN,WANNIAN COUNTY,JIANGXI PROV.,CHINA,ZIP
Lianyungang Ningkang Chemical Co., Ltd

Contact:.+86-518-88588008

Address:http://www.chemnk.com
Wuhan Jadechem International Trade Co.,Ltd.

website:http://www.jadechem-intl.com

Contact:+86-27-83527060

Address:Room 502,Building C11,Software new city No.8,Huacheng Avenue,East Lake High-tech development zone,Wuhan,Hubei,China

Relevant to this article

Red Phosphorescent Bis-Cyclometalated Iridium Complexes with Fluorine-, Phenyl-, and Fluorophenyl-Substituted 2-Arylquinoline Ligands

Doi:10.1002/chem.201504392
(2016)
Regioselectivity in Cyclohexadienone Photochemistry. Role of Zwitterions in Type A Photochemical and Dark Rearrangements. Mechanistic and Exploratory Organic Photochemistry

Doi:10.1021/jo01312a013
(1980)
Reaction of β-Keto Esters with 2-Amino-1,3,4-thiadiazoles. A Reinvestigation

Doi:10.1021/jo01312a012
(1980)
SYNTHESIS AND CHARACTERIZATION OF Rh3(μ-PPh2)3(CO)3(PPh3)2: A NOVEL TRIANGULAR RHODIUM CLUSTER

Doi:10.1016/S0022-328X(00)81237-1
(1980)
ACETALS AS CHIRAL AUXILIARIES Part 4 Asymmetric synthesis of γ,δ-ethylenic aldehydes An approach to the California Red scale pheromone

Doi:10.1016/S0040-4039(00)96125-2
(1987)
Highly enantioselective reaction of lithiated N-Boc-thiazolidine: A new chiral formyl anion equivalent

Doi:10.1039/b408509d
(2004)

Article Doi