
Journal of Organic Chemistry p. 3133 - 3139 (1986)
Update date:2022-08-05
Topics:
Woulfe, Steven R.
Miller, Marvin J.
The synthesis of substituted <<3(S)-(acylamino)-2-oxo-1-azetidinyl>thio>acetic acids (6, thiamazins) is described.Various substituted 3(S)-(acylamino)-2-azetidinones were sulfenylated with tert-butyl (phtalimidothio)acetate.Deprotection of the tert-butyl ester with trifluoroacetic acid provided the title compounds.In sharp contrast to their oxygen analogues (oxamazins), the thiamazins were devoid of biological activity.
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