Synthesis and local anesthetic activity of benzo[b]furan derivatives.

Article abstract of DOI:10.1002/jps.2600670136

Several 2-dialkylaminoethyl 3-methyl-2-benzo[b]furancarboxylates, 2-dialkylaminoethyl 3-methyl-2-benzo[b]furancarbamates, and 3-methyl-2-benzo[b]furancarboxamide derivatives were prepared and tested for local anesthetic activity. Piperidinoethyl 3-methyl-2-benzo[b]furancarbamate, 2-diethylaminoethyl 3-methyl-2-benzo[b]-furancarboxylate, and N-(2-diethylaminoethyl)-3-methyl-2-benzo[b]-furancarboxamide were the most potent.