Journal of Organic Chemistry p. 1109 - 1113 (1980)
Update date:2022-07-30
Topics:
Weeks, Paul D.
Brennan, Thomas M.
Brannegan, Daniel P.
Kuhla, Donald E.
Elliot, Mark L.
et al.
A one-pot synthesis of maltol and ethylmaltol is reported.Treatment of methylfurfuryl alcohol with 2 equiv of halogen affords good yields of 4-halo-6-hydroxy-2-methyl-2H-pyran-3(6H)-ones (8), which need not be isolated and can be converted to maltol by aqueous hydrolysis in the same vessel.A similar sequence employing ethylfurfuryl alcohol yields ethylmaltol.By a related series of reactions, isomaltol (9) can be converted to maltol.
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