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31. Compound 26 was prepared by coupling the known adenine
derivative Ad(Cbz)CH2CO2H to the backbone moiety 7 using
the same protocol as for the coupling of the Thy-acetic acid 8
with 7 (Scheme 1). Analytical data of compound 26: 1H NMR
(400 MHz, CDCl3) d: 1.44 (s, 9H), 3.92 (dd, 1H, J¼14.4,
7.2 Hz), 4.25–4.62 (m, 4H), 4.91 (d, 1H, J¼16.8 Hz), 5.12 (m,
1H), 5.18 (m, 1H), 5.30 (s, 2H), 5.77–5.93 (m, 1H), 6.64 (br,
1H), 7.22–7.53 (m, 4H), 7.71 (d, 1H, J¼7.2 Hz), 8.29 (br, 1H),
8.79 (s, 1H). 13C NMR (75 MHz, DMSO-d6) d: 12.5, 14.6,
21.3, 28.6, 49.1, 50.7, 60.3, 80.1, 108.4, 118.7, 125.8, 126.2,
129.6, 130.8, 133.2, 133.2, 135.9, 142.5, 151.6, 154.0, 164.9,
167.2, 170.8. ESþ MS m/z: 572.3 (MþH)þ; ES2 MS m/z:
570.3 (M2H)2.
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