SYNTHESES TOTALES ET ETUDES DE LIGNANES BIOLOGIQUEMENT ACTIFS-II. APPLICATION DE L'α-HYDROXYALKYLATION DE β-BENZYL χ-BUTYROLACTONE A LA CREATION DES SQUELETTES PHENYL TETRALINE ET BISBENZOCYCLOOCTADIENES. SYNTHESE TOTALE DU (+/-) PODORHIZOL, DE LA (+/-) P

Article abstract of DOI:10.1016/0040-4020(82)80075-6

The use of lithium hexamethyldisilylamide (LHDS) in α-hydroxyalkylation of β-(3,4-methylenedioxybenzyl)-χ-butyrolactone gives high yields of (+/-) podorhizol and (+/-) epi-podorhizol as a 1:1 diastereoisomer mixture.Cyclisation of both alcohols using trif