Bioorganic and Medicinal Chemistry Letters p. 163 - 168 (1997)
Update date:2022-08-03
Topics:
Cherney, Robert J.
Swartz, Stephen G.
Patten, Arthur D.
Akamike, Emeka
Sun, Jung-Hui
Kaltenbach III, Robert F.
Seitz, Steven P.
Behrens, Carl H.
Getahun, Zelleka
Trainor, George L.
Vavala, Mike
Kirshenbaum, Mindy R.
Papp, Lisa M.
Stafford, Margaret P.
Czerniak, Philip M.
Diamond, Richard J.
McRipley, Ronald J.
Page, Roni J.
Gross, Janet L.
Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts in mice. These studies identified DMP 315 as a potent, water soluble antitumor agent.
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