Journal of Medicinal Chemistry p. 13 - 20 (1980)
Update date:2022-08-03
Topics:
Rachlin, Schneur
Bramm, E.
Ahnfelt-Ronne, I.
Arrigoni-Martelli, E.
A variety of basic N,N',N''-trisubstituted guanidines was prepared and tested for antiinflammatory activity.Compounds with a thiazoylguanidine moiety linked to the 4 position of the 2-methylquinoline ring exhibited fairly high antiinflammatory activity.Optimal activity was associated with the presence of N-cycloalkyl substituents on N''-4-(2-methylquinolyl)-N'-2-thiazolylguanidine.Pharmalogical data on N-cyclohexyl-N''-4-(2-methylquinolyl)-N'-2-thiazolylguanidine (SR 1368, 44) are presented and discussed.
View MoreJiangxi Province Bethel Pharmaceutical Co., Ltd.
Contact:+86-795-259 3456 ，+86-15957688008 13566650571
Address:Huangjindui Chemical Park， Shanggao County ，Yichun city，Jiangxi Province
Wuhan Fortuna Chemical Co.,Ltd
website:http://www.fortunachem.com
Contact:86-27-59207850
Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China
Contact:86-513-84128750/13773795976
Address:No.48.Youyi West Road ,Rudong Development Zone,Jiangsu Province,China
SHAANXI TOP PHARM CHEMICAL CO.LTD
Contact:+86-029-85733403
Address:No.108 ,west sector,south er huan,xi'an,china
Zhejiang kehong chemical co., ltd
Contact:0086-575-85522000
Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Doi:10.1016/j.tetlet.2014.05.102
(2014)Doi:10.1021/jo01292a035
(1980)Doi:10.1021/acs.orglett.0c00802
(2020)Doi:10.1021/jo01292a029
(1980)Doi:10.1081/NCN-120027820
(2004)Doi:10.1002/adsc.201200707
(2013)
