Journal of Medicinal Chemistry p. 13 - 20 (1980)
Update date:2022-08-03
Topics:
Rachlin, Schneur
Bramm, E.
Ahnfelt-Ronne, I.
Arrigoni-Martelli, E.
A variety of basic N,N',N''-trisubstituted guanidines was prepared and tested for antiinflammatory activity.Compounds with a thiazoylguanidine moiety linked to the 4 position of the 2-methylquinoline ring exhibited fairly high antiinflammatory activity.Optimal activity was associated with the presence of N-cycloalkyl substituents on N''-4-(2-methylquinolyl)-N'-2-thiazolylguanidine.Pharmalogical data on N-cyclohexyl-N''-4-(2-methylquinolyl)-N'-2-thiazolylguanidine (SR 1368, 44) are presented and discussed.
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