Synthesis of (±)-11-hydroxy-Δ9-6a,10a-trans-tetrahydrocannabinol and other 11-substituted Δ9-tetrahydrocannabinoids

Article abstract of DOI:10.1021/jo01292a052

11-Substituted Δ⁹-tetrahydorcannabinoids, including the racemate of the biologically important 11-hydroxy-Δ⁹-6a,10a-trans-tetrahydrocannabinol and the corresponding 11-mercapto analogue, are synthesized via condensation of olivetol with the terpenoid synthon 3 prepared from 6-methylhept-5-en-2-one.