Cyclophosphamide potentiation and aldehyde oxidase inhibition by phosphorylated aldehydes and acetals

Article abstract of DOI:10.1021/jm00177a018

Fourteen phosphorylated acetals and aldehydes were synthesized for testing in vitro as inhibitors or substrates of aldehyde oxidase, an enzyme involved in the conversion of aldophosphamide to inactive carboxyphosphamide, and for concurrent in vivo adminis