A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates

DOI: 10.1021/ol049267j

Source and publish data:

Organic Letters p. 2257 - 2260 (2004)

Update date:2022-08-03

Topics:

Authors:

Wu, Weidong

Meyers, Caren L. Freel

Borch, Richard F.

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Article abstract of DOI:10.1021/ol049267j

A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.

Full text of DOI:10.1021/ol049267j

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