Russian Journal of General Chemistry p. 787 - 793 (2020)
Update date:2022-07-31
Topics:
Agaronyan, A. S.
Danielyan, I. S.
Dilanyan, S. V.
Harutyunyan, A. A.
Hovsepyan, T. R.
Minasyan, N. S.
Nersesyan, L. E.
Abstract: Bis-1,2,4-triazoles with aryl and alkyl linkers were synthesized. In order to increase their hydrophilicity and potential biological activity, pharmacophore electron-deficient groups (carboxylic, carboxamide, nitrile) were introduced into the molecule. Functionalized compounds revealed a new type of biological activity such as inhibition of the level of methylation of tumor DNA.
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