Renin inhibitors. Synthesis of transition-state analogue inhibitors containing phosphorus cid derivatives at the scissile bond

Article abstract of DOI:10.1021/jm00127a041

The synthesis of five amino phosphorus derivatives, 1a-e, is described. The derivatives were incorporated into a series (18) of analogues of the 5-14 portion of angiotensinogen, in most cases at the scissile Leu-Val bond. The resultant compounds were test