Journal of Medicinal Chemistry p. 462 - 465 (1980)
Update date:2022-08-05
Topics:
Wright, William B.
Greenblatt, Eugene N.
Day, Ivana P.
Quinones, Nicanor Q.
Hardy, Robert A.
Four 11-(1-piperazinyl)5H-pyrrolo<2,1-c><1,4>benzodiazepines were prepared and evaluated as central nervous system agents.All were active psychotropic agents as determined by animal screening tests.The most interesting compound, 11-(1-piperazinyl)-5H-pyrrolo<2,1-c><1,4>benzodiazepine, showed dual activity as an antidepressant against tetrabenazine depression and as a neuroleptic as measured by protection vs. amphetamine lethality in grouped mice.
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