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Synthesis of antimicrobial agents. VI. Studies on the synthesis of furo[3,2-b][1,8]naphthyridine derivatives

DOI: 10.1248/cpb.32.4914

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 4914 - 4922 (1984)

Update date:2022-08-02

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Authors:

HayakawaHayakawa

SuzukiSuzuki

SuzukiSuzuki

TanakaTanaka

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Article abstract of DOI:10.1248/cpb.32.4914

As a part of our search for new antibacterial agents, 5-ethyl-8-oxo-5,8-dihydrofuro[3,2-b][1,8]naphthyridine-7-carboxylic acid and its 2,3-dihydrofuro derivative, the 4-aza analogue of droxacin, were synthesized and their antibacterial activities were tested. Both compounds exhibited high antibacterial activities and a broad antibacterial spectrum. In an attempt to find a suitable method for industrial-scale synthesis of these compounds, several methods for the furan ring cyclization of 6,7-disubstituted 1,8-naphthyridine-3-carboxylate derivatives were compared.

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Full text of DOI:10.1248/cpb.32.4914

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Products guided by the article

Product name:Furo[3,2-b][1,8]naphthyridine-7-carboxylic acid, 5-ethyl-5,8-dihydro-8-oxo-, ethyl ester

Cas No:73101-91-4

73101-91-4

R&D Labs maybe for 73101-91-4

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