AMORPHASTILBOL, AN ANTIMICROBIAL AGENT FROM AMORPHA NANA

Article abstract of DOI:10.1016/S0031-9422(00)81048-1

Key Word Index - Amorpha nana; Leguminosae; amorphastilbol; 3,5-dihydroxy-7,4'-dimethoxyflavone; antimicrobial agents; chemistry; bioactivity.Abstract - Bioassay-directed fractionation of Amorpha nana demonstrated that the anti Gram positive/antitubercular constituent is amorphastilbol.The chemical structure of amorphastilbol was confirmed by chemical transformation to known (Radula variabilis) dihydroamorphastilbol and its methyl ether.Inactive 3,5-dihydroxy-7,4'-dimethoxyflavone was detected in this plant for the first time and identified by interconversion with kaempferol.All compounds were evaluated in vitro for antimicrobial spectrum and potency.