Phytochemistry p. 1481 - 1484 (1985)
Update date:2022-08-03
Topics:
Mitscher, Lester A.
Gollapudi, Sitaraghav Rao
Drake, Steven
Oburn, David S.
Key Word Index - Amorpha nana; Leguminosae; amorphastilbol; 3,5-dihydroxy-7,4'-dimethoxyflavone; antimicrobial agents; chemistry; bioactivity.Abstract - Bioassay-directed fractionation of Amorpha nana demonstrated that the anti Gram positive/antitubercular constituent is amorphastilbol.The chemical structure of amorphastilbol was confirmed by chemical transformation to known (Radula variabilis) dihydroamorphastilbol and its methyl ether.Inactive 3,5-dihydroxy-7,4'-dimethoxyflavone was detected in this plant for the first time and identified by interconversion with kaempferol.All compounds were evaluated in vitro for antimicrobial spectrum and potency.
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